We chose Ajijic. Guad was a city, not where we wanted to live. Chapala is nice, very Mexican and for us too big a jump into the deep end of the pool (acculturation). Ajijic has a large ****** population, but not like the resort towns, like PV. Ajijic will allow us to slowly move into a new world, still allow us to learn and not feel totally isolated due to language and culture as we learn it. But, contrarily, we have seen those in Ajijic who do not appear to want to acculturate into the society they have chosen to live. For us, that is contrary to the reason why one becomes an expat.
You need to decide individually how you will react to a totally new environment and culture and whether you are ready and how much courage you have to face it.