It depends quite a bit on your circumstances. Ideally, you'd want to move to an area where you have family - because of the frequent and long school holidays, you need some form of child care while you're working and the kids are off from school. In France, most people seem to plant the kids with Grandma and Grandpa, but obviously that's not an alternative for us foreigners.
The other matter is the "working" part. It depends quite a bit on your line of work and where you're most likely to be able to find employment.
Do you have any areas currently in mind? I'm sure folks here could give you some feedback on specific areas more easily than picking a place out of the 30,000+ towns in France.