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South Africa is in the list of countries with a high rabies risk so you will need to follow this procedure:

If your pet is entering Spain from a high-rabies country, your pet must be microchipped, then vaccinated for rabies (in that order). After waiting 30 days, a rabies titer test (FAVN) must be administered. (Have your vet scan your pet's microchip prior to the titer test.)

Samples must be processed at approved laboratories. Assuming test results are within acceptable limits, your pet can enter Spain no sooner than 3 calendar months after the date the blood was drawn and avoid quarantine.
Spain Pet Passport - Current Dog and Cat Import Requirements
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