You should be OK, however just keep in mind that the Visa does not guarantee you entry to the US every time; it's up to the port official as to whether or not they feel the status is being abused and they can deny you entry at any time.

However as long as you can demonstrate that you have strong financial ties in Spain and that you have no thoughts of immigration to the US then I'd imagine you'll be fine however there's always the possibility that you'll not be.