Since you will be working from home and since you have children, your first priority will be to investigate the private schools at Lake Chapala and in Guadalajara for your children. Since the airport is halfway between Chapala and Guadalajara, you may prefer Chapala for air quality, safety and the expat community which, although older, supports the availability of products, entertainment and publications in English, etc. Use your Google to search for "real estate in Chapala and Ajijic" or just go to chapala.com for a start.