Funny, I was thinking the same thing about your wife's job of care manager - there really isn't an equivalent in the US. That will make it kind of up to her to "sell" it to a potential employer. But, they do have a variety of "case manager" positions with the various health care organizations in the Boston area. The jobs are medically oriented - but it's certainly worth looking into.

Take a look at the online version of the Boston Globe (Boston.com / Monster - Boston Area Jobs) . Every once in a while they run a big section of job ads related to health care professions - but these include all sorts of administrative jobs. There are also a number of "job fairs" in the Boston area - usually in specialty fields (IT, health care, education, etc.) - but if you can catch one of those, it would be ideal. The Globe's job ad section usually includes lots of articles about job hunting and career fields, too, which could be useful.
Cheers,
Bev