Another bit of information that would help in advising you is where are you coming from, and what is your visa situation for Canada?

Your medical insurance will start after you start working - but you probably want some sort of travel or expat policy to tide you over until you start working and the national health insurance kicks in.

The initial settling in period can be heaven or hell - it depends on your resources and your attitude. Job hunting is a stressful experience, particularly when you're a foreigner because it will be up to you to prove yourself to a potential employer. In the meantime, you're also trying to set up housekeeping and probably looking for an apartment at the same time, without a local credit history to fall back on.

Be prepared to have to explain your CV in Canadian terms (your education, especially) - which means you need to understand a bit about how the Canadian educational system works, at least at the university level. Your wife should try to find the Canadian equivalents for her nursing training and experience and explain her background in those terms.
Cheers,
Bev