Of course, just like any first time driver anywhere. You will need to be settled with an FM3 and an address. In Jalisco, you can get a four year license; some other states may only issue you a license for one year as a 'tourist' unless you eventually achieve 'inmigrado' status or become a naturalized citizen.

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Read "Streets of Glass" to discover the experience of a retired couple's permanent move to Lake Chapala, Jalisco, Mexico.
PM for details.