Yes different flavours, all.
If you really want young, arty, then just go for downtown TO(expensive rent for a little apartment). But, thats where all my friends gravitate to for the arts/culture/nightlife, diversity.
If you are an artisan some of the smaller towns would be good. Like St. Jacobs(right outside Waterloo). Otherwise it would be downtown in smaller cities with universities I would recommend. I really like Guelph. Beautiful smaller city. Live close to downtown....avoid suburbs in any city.
I can't really speak for Eastern Ontario as I have only briefly visited a few places.